2. Signaling Pathways
  3. Immunology/Inflammation
  4. Scavenger Receptor Class B type I (SR-BI）

Scavenger Receptor Class B type I (SR-BI）

Scavenger receptor class B member 1; SRB1; CD36 and LIMPII analogous 1 (CLA-1); CD36 antigen-like 1

Scavenger receptor class B type I (SR-BI) is a physiologically relevant HDL receptor that mediates the selective uptake of HDL-derived cholesteryl esters (CEs) in vitro and in vivo. SR-BI is a member of the class B scavenger receptor family, which in mammals includes the cluster determinant 36 (CD36) family, lysosomal integral membrane protein II (LIMPII, a lysosomal protein), and SR-BII, an SR-BI isoform with an alternative C-terminal cytoplasmic tail. SR-BI is primarily located on the cell surface, where its expression is regulated by trophic hormones (adrenocorticotropic hormone [ACTH] or the gonadotropins luteinizing hormone [LH] or follicle-stimulating hormone [FSH]), as well as regulating steroid hormone production. SR-BI affects the function of multiple vascular cells associated with atherosclerosis. SR-BI is also involved in regulating platelet function and mediating platelet-HDL interactions[1].

Scavenger Receptor Class B type I (SR-BI） Related Products (3):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-163541
    SMS121
    		Inhibitor 98.75%
    SMS121 is a CD36 inhibitor with a KD values of about 5 µM. SMS121 reduces the uptake of lipids and inhibits cell viability in acute myeloid leukemia cells. SMS121 has antitumor activity.
    SMS121
  • HY-P990352
    Anti-CD36 Antibody
    		Inhibitor
    Anti-CD36 Antibody is a humanized antibody expressed in CHO that targets CD36. The Anti-CD36 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CD36 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-CD36 Antibody
  • HY-168371
    1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC
    1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC (13-HODE-PC) is an oxidized phospholipid that contains Palmitic acid (HY-N0830) and 13(S)-HODE (HY-113884B) at the sn-1 and sn-2 positions, respectively. 1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC has the ability to compete for the binding of 125I-NO2-LDL (5 g/mL) to CD36-transfected 293 cells, with the IC50 of ＞ 200 μM.
    1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC